diff --git a/src/core/settings.cpp b/src/core/settings.cpp
index d3886c4ec..64a3c69d3 100644
--- a/src/core/settings.cpp
+++ b/src/core/settings.cpp
@@ -184,4 +184,9 @@ void RestoreGlobalState() {
     values.sound_index.SetGlobal(true);
 }
 
+void Sanitize() {
+    values.use_asynchronous_gpu_emulation.SetValue(
+        values.use_asynchronous_gpu_emulation.GetValue() || values.use_multi_core.GetValue());
+}
+
 } // namespace Settings
diff --git a/src/core/settings.h b/src/core/settings.h
index 3eb336f75..a64debd25 100644
--- a/src/core/settings.h
+++ b/src/core/settings.h
@@ -526,4 +526,7 @@ void LogSettings();
 // Restore the global state of all applicable settings in the Values struct
 void RestoreGlobalState();
 
+// Fixes settings that are known to cause issues with the emulator
+void Sanitize();
+
 } // namespace Settings
diff --git a/src/yuzu/configuration/config.cpp b/src/yuzu/configuration/config.cpp
index 9e9b38214..d25b99a32 100644
--- a/src/yuzu/configuration/config.cpp
+++ b/src/yuzu/configuration/config.cpp
@@ -1368,11 +1368,13 @@ void Config::WriteSettingGlobal(const QString& name, const QVariant& value, bool
 
 void Config::Reload() {
     ReadValues();
+    Settings::Sanitize();
     // To apply default value changes
     SaveValues();
     Settings::Apply();
 }
 
 void Config::Save() {
+    Settings::Sanitize();
     SaveValues();
 }